It's 2015, and Anne Hatley is leaving her North Carolina home for a Long Island research lab called the Colony. Anne, who was born with a genetic mutation that left her only one leg, will be donating stem cells for gene research in exchange for a new leg. But after meeting others with deficiencies, including carriers of the "suicide gene" and "obesity gene", Anne questions how much genetics really determine a person's life. She goes forward with the treatment, but there may be a price to pay for perfection.