The year is 1976, and the first shots are being fired in the narcotics and human-trafficking war. Colt Freeman and his partner, Snyder, want only to preserve their small piece of the marijuana trade. Like a modern-day Butch Cassidy and Sundance Kid, they do their work with proficiency and stealth and, when necessary, deadly force.

Hundreds of miles away, a law enforcement task force patrols the border between the United States and Mexico, the desolate no man's land that separates misery and prosperity. They seek to curb the unspeakable violence that feeds off the ever-growing number of illegal immigrants who find themselves at the mercy of ruthless 'coyotes' they have paid to guide them in their desperate crossing.

Farther southwest, an elegant hacienda is nestled behind protective walls at an isolated ranch on the coast of the Sea of Cortez. Beyond the well-guarded gates, Miguel Zamora has placed himself at the center of a powerful circle of corrupt Mexican officials on the cusp of establishing ties with Columbian drug cartels.

Zamora, driven by avarice and steeped in paranoia, begins to seize control of his world with a singular and savage brutality that threatens to unleash a firestorm of bloodshed on both sides of the border.

Snyder and Colt decide to cash in on one last marijuana harvest in one final run down the coast before leaving their outlaw lives behind them. But when their meticulously-planned scheme comes undone, it forces them into a rash and hazardous escape from the law and directly into the crossfire of an internecine narcotics war that no one had seen coming.