Fifteen years after graduating from Harvard, five close friends on the cusp of middle age are still pursuing an elusive happiness and wondering if they've wasted their youthful opportunities. Jules, already a famous actor when she arrived on campus, is changing in mysterious ways but won't share what is haunting her. Mariam and Rowan, who married young, are struggling with the demands of family life and starting to regret prioritising meaning over wealth in their careers. Eloise, now a professor who studies the psychology of happiness, is troubled by her younger wife's radical politics. And Jomo, founder of a luxury jewellery company, has been carrying an engagement ring around for months, unsure whether his girlfriend is the one.

The soul searching begins in earnest at their much-anticipated college reunion weekend on the Harvard campus, when the most infamous member of their class, Frederick - senior advisor and son of the recently elected and loathed US President - turns up dead.

Old friends often think they know everything about one another, but time has a way of making us strangers to those we love - and to ourselves....