This brilliant new novel by an American master, the author of Ragtime, The Book of Daniel, Billy Bathgate, and The March, takes us on a radical trip into the mind of a man who, more than once in his life, has been the inadvertent agent of disaster.

Speaking from an unknown place and to an unknown interlocutor, Andrew is thinking, Andrew is talking, Andrew is telling the story of his life, his loves, and the tragedies that have led him to this place and point in time. And as he confesses, peeling back the layers of his strange story, we are led to question what we know about truth and memory, brain and mind, personality and fate, about one another and ourselves. Written with psychological depth and great lyrical precision, this suspenseful and groundbreaking novel delivers a voice for our times - funny, probing, skeptical, mischievous, profound. Andrew's Brain is a surprising turn and a singular achievement in the canon of a writer whose prose has the power to create its own landscape, and whose great topic, in the words of Don DeLillo, is "the reach of American possibility, in which plain lives take on the cadences of history."