Supernatural, a three-time People's Choice Award winner for Favorite Sci-Fi/Fantasy TV Show and Tumblr's 2015 Most Reblogged "Live Action TV", has made a name for itself by supporting and encouraging its fans to "always keep fighting", and a memorable line from early in the show's run, "Family don't end with blood", became an inspiring mantra for many who found community in the fandom.

In 25 powerful chapters written by Supernatural's actors and fans, including series lead Jared Padalecki, plus special messages from Jensen Ackles, Misha Collins, and Mark Sheppard, Family Don't End with Blood: Cast and Fans On How Supernatural Has Changed Lives examines the far reach of the show's impact for more than a decade. Supernatural has inspired fans to change their lives, from getting "sober for Sam" to escaping a cult to pursuing life-long dreams.

But fans aren't the only ones who have been changed. The actors who bring the show to life have also found, in the show and its community, inspiration, courage, and the strength to keep going when life seemed too hard.